Molecule structure of an antibody fab fragment.

Fab Fragment production

Fab fragments (Fabs) are the antigen-binding fragments of a monoclonal antibody. Compared to a full-length antibody, the fragment crystallizable region (Fc) region which binds to specific proteins and cell surface receptors, has been removed. These molecules have numerous therapeutic applications and have been produced in both mammalian and microbial systems.

Molecule structure of an antibody fab fragment.

Molecule structure of an antibody fab fragment.

Boehringer Ingelheim BioXcellence™ has long standing experience in manufacturing Fabs in both mammalian (CHO cells) and microbial systems. We provide platform approaches and highly tailored, royalty-free solutions using our large portfolio of expression systems and manufacturing technologies. Our innovative high-throughput process development solutions serve to reduce development time and facilitate in-depth process understanding. Representative scale-down models are in place to ensure seamless scale-up and efficient process characterization.

Boehringer Ingelheim BioXcellence™ is constantly investigating and developing new technologies to increase speed, productivity, robustness and know-how of our in-house bioprocesses as well as in collaboration with industrial and academic partners. Tools for Fab production in microbial systems are constantly being further developed; for example, we are currently  collaborating with the University of Natural Resources and Life Sciences in Vienna (https://www.boehringer-ingelheim.at/de/biopharma/biopharma/kooperation-cd-labor).